VIII Reunión de la Sociedad de Ginecología Oncológica de Castilla y León VII Reunión y I Online SoGOCyL 2021 Jornadas SoGOCyL 2020 Conclusiones de las Jornadas SoGOCyL 2019
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VIII Reunión de la Sociedad de Ginecología Oncológica de Castilla y León

Este 2023 nos complace anunciar que la VIII Reunión de la SoGOCyL tendrá lugar los días 16 y 17 de noviembre en Valladolid.

VII Reunión y I Online SoGOCyL 2021

En 2021 la Reunión de la Sociedad de Ginecología Oncológica de Castilla y León se celebrará online los días 2 y 3 de junio.

Jornadas SoGOCyL 2020

La VII Reunión de la Sociedad de Ginecología Oncológica de Castilla y León tendrá lugar los días 7 y 8 de mayo de 2020 en León.

Conclusiones de las Jornadas SoGOCyL 2019

Éstas son las conclusiones que los profesionales extraemos de la VI Reunión de la Sociedad de Ginecología Oncológica y Patología Mamaria de Castilla y León.

Inicio The Evolving Role of Adjuvant Therapy in Endometrial Cancer

The Evolving Role of Adjuvant Therapy in Endometrial Cancer

Viernes, 21 de Enero de 2011 23:25

The Evolving Role of Adjuvant Therapy in Endometrial Cancer

Crit Rev Oncol Hematol. 2011 May; 78(2):79-91; A Gadducci, C Greco

Abstract

Extra-fascial total hysterectomy and bilateral salpingo-oophorectomy with or without lymph node dissection is the initial treatment for endometrial cancer. Unresolved scientific controversy exists regarding the selection of patients who may benefit from lymphadenectomy, the magnitude of such benefit, and the role of adjuvant therapy. External pelvic irradiation has been shown to reduce loco-regional recurrences without improving survival. Meta-analyses of randomized trials indicate that external pelvic irradiation offers a significant benefit in terms of survival only in high-risk disease (i.e. stage Ic grade 3). Intermediate risk patients (i.e. stage Ib grade 3 disease), therefore, may be treated with adjuvant intravaginal brachytherapy alone to avoid the risk of side effects associated with pelvic irradiation. Overall, patients with clinically early endometrial cancer develop relapses in less than 20% of cases, mostly at distant sites.

 

 

Randomized trials comparing adjuvant external pelvic irradiation versus adjuvant chemotherapy have shown conflicting clinical results. Chemotherapy seems to prevent or delay distant spread more than radiotherapy, while radiotherapy appears to prevent or delay local relapses more than chemotherapy, although these trends fail to achieve statistical significance.

Recent evidence from a randomized trial indicates that sequential external pelvic irradiation with or without brachytherapy and platinum-based chemotherapy result in significantly better progression-free survival than radiotherapy alone in patients with high-risk endometrial cancer. Reliable surgical/pathological variables predictive of high risk of distant failure may be used to identify a subset of patients suitable for randomized trials of adjuvant chemotherapy with or without external irradiation.

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