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Jornadas SoGOCyL 2018

Se celebrará la V Reunión de la Sociedad de Ginecología Oncológica y Patología Mamaria de Castilla y León los días 3, 4 y 5 de Mayo de 2018

Jornadas SoGOCyL 2016

Se celebrará la IV Reunión de la Sociedad de Ginecología Oncológica y Patología Mamaria de Castilla y León los días 5, 6 y 7 de Mayo de 2016

I JORNADA DE CIRUGIA ONCOLOGICA PERITONEAL

Se celebra el 25 de Noviembre de 2014 a las 10:00 horas en el Salón de Actos del Hospital Universitario Río Hortega de Valladolid...

Reunión de presentación de la UNIDAD DE REFERENCIA REGIONAL DE CIRUGIA ONCOLOGICA PERITONEAL

Se celebra el 3 de Noviembre de 2014, 17:00 horas en Salón de Actos de la Gerencia Regional de Salud...

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Fertility considerations in the management of gynecologic malignancies

Review

Nicole Noyes (a), Jaime M. Knopman (a), Kara Long (b), Jaclyn M. Coletta (c), Nadeem R. Abu-Rustum (b)

(a) Division of Reproductive Endocrinology, New York University School of Medicine, New York, NY, USA. (b) Division of Gynecologic Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. (c) Division of Maternal Fetal Medicine, Columbia University Medical Center, New York, NY, USA

Keywords: Fertility preservation, Oocyte cryopreservation, Cancer, Parenthood, Quality-of-life

Goals. Gynecologic cancers represent a significant proportion of malignancies affecting women. Historically, cancer treatment focused primarily on eradicating disease, irrespective of the impact on fertility. The implementation of early detection protocols and advanced treatment regimens has resulted in improved prognosis for gynecologic cancer patients. With this improvement, more attention is now paid to quality-oflife issues. Fertility preservation (FP) has become an integral component in the selection and execution of gynecological cancer management. In this report we address gynecologic malignancies as they relate to future fertility potential.

Methods. We review reproductive principles such as ovarian reserve, uterine function, cervical competence, and early obstetrical management, as well as available FP methods. In addition, we discuss the potential damage that cancer and cancer treatments can impart on the female reproductive system. We offer general recommendations regarding baseline screening tests useful in assessing the feasibility of FP. Lastly, cancer-specific FP methods are presented.

Pocas niñas, adolescentes y mujeres jóvenes se ponen la vacuna contra el virus del papiloma humano (VPH) y muchas de las que inician el régimen no reciben las tres dosis, según revela una investigación reciente.

Aunque estudios han mostrado que la vacuna contra el VPH es segura y eficaz contra varias cepas del virus de transmisión sexual, apenas un tercio de las adolescentes y mujeres jóvenes que inician la serie de tres dosis la completan, y casi tres cuartas partes ni siquiera la comienzan, según una investigación que se presenta esta semana en la reunión anual de la Asociación Estadounidense de Investigación del Cáncer (American Association of Cancer Research) en Filadelfia.

"Entre las mujeres que son elegibles para esta vacuna y que podrían beneficiarse potencialmente, las tasas de vacunación no son suficientes para prevenir al máximo el cáncer de cuello uterino", señaló la autora del estudio J. Kathleen Tracy, profesora asistente de epidemiología y salud pública de la Facultad de medicina de la Universidad de Maryland en Baltimore.

 "Esto resalta la necesidad de promociones de salud pública y patrones de práctica para fomentar la administración de las vacunas, o al menos discutir las ventajas y desventajas", comentó Tracy.

Tracy comenzó un estudio para ver si los mensajes de texto animarán a las muje

 res de 18 a 26 años a cumplir con sus citas de seguimiento para las próximas dosis de la vacuna.

Según la información de respaldo del resumen, alrededor del 30 por ciento de las personas de 14 a 19 años de edad que son sexualmente activas están infectadas con VPH en un momento dado. Con el tiempo, la infección persistente puede llevar a cáncer del cuello uterino.

Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study

The Lancet, Volume 373, Issue 9658, Pages 125 - 136, 10 January 2009 <Previous Article|Next Article>doi:10.1016/S0140-6736(08)61766-3Cite or Link Using DOI

Published Online: 13 December 2008

The writing committee on behalf of the ASTEC study group‡

Summary

Background

Hysterectomy and bilateral salpingo-oophorectomy (BSO) is the standard surgery for stage I endometrial cancer. Systematic pelvic lymphadenectomy has been used to establish whether there is extra-uterine disease and as a therapeutic procedure; however, randomised trials need to be done to assess therapeutic efficacy. The ASTEC surgical trial investigated whether pelvic lymphadenectomy could improve survival of women with endometrial cancer.

 

Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis

The Lancet, Volume 373, Issue 9658, Pages 137 - 146, 10 January 2009 <Previous Article|Next Article>doi:10.1016/S0140-6736(08)61767-5Cite or Link Using DOI

Published Online: 13 December 2008

The ASTEC/EN.5 writing committee on behalf of the ASTEC/EN.5 Study Group‡

Summary

Background

Early endometrial cancer with low-risk pathological features can be successfully treated by surgery alone. External beam radiotherapy added to surgery has been investigated in several small trials, which have mainly included women at intermediate risk of recurrence. In these trials, postoperative radiotherapy has been shown to reduce the risk of isolated local recurrence but there is no evidence that it improves recurrence-free or overall survival. We report the findings from the ASTEC and EN.5 trials, which investigated adjuvant external beam radiotherapy in women with early-stage disease and pathological features suggestive of intermediate or high risk of recurrence and death from endometrial cancer.

Methods

Between July, 1996, and March, 2005, 905 (789 ASTEC, 116 EN.5) women with intermediate-risk or high-risk early-stage disease from 112 centres in seven countries (UK, Canada, Poland, Norway, New Zealand, Australia, USA) were randomly assigned after surgery to observation (453) or to external beam radiotherapy (452). A target dose of 40—46 Gy in 20—25 daily fractions to the pelvis, treating five times a week, was specified. Primary outcome measure was overall survival, and all analyses were by intention to treat. These trials were registered ISRCTN 16571884 (ASTEC) and NCT 00002807 (EN.5).

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